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Vital Background of Bactrim, its General Use and Effectiveness

The following article’s aim is to share general drug overview, summarize common indications for use, list down associated side effects for all patients.

Drug Overview and Indications

Bactrim (sulfamethoxazole and trimethoprim) represents a blend of 2 antibiotics applied for treatment of acute otitis media, urinary tract infections, Shigellosis, bronchitis, traveler’s diarrhea, Pneumocystis pneumonia, methicillin-resistant Staphylococcus aureus (MRSA), as well as other associated bacterial infections susceptible to that type of antibiotic.

Bactrim is prescribed to treat Pneumocystis jirovecii pneumonia, enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei among pediatric (2 months old and above) and adult patients.
In addition, Bactrim is used to cure severe or complex urinary tract infections among adults and pediatric patients of 2 months old and above caused by susceptible strains of Klebsiella species, Escherichia coli, Morganella morganii, Enterobacter species, Proteus vulgaris and Proteus mirabilis in cases where Bactrim cannot be taken orally and when the organism is not susceptible to single-agent antibacterial meds efficient inside urinary tract.

Proper Dosage and Apt Administration

The following dosage is suitable for adults and pediatric patients (2 months old and above). The highest permitted dose for daily intake is 60 mL (960 mg trimethoprim). The following list includes specific health disorders and corresponding dosage as well as treatment duration:
Pneumocystis jirovecii Pneumonia – 15-20 mg/kg (in 3 – 4 equally split doses) during 14 days;
Severe Urinary Tract Infections – 8-10 mg/kg (in 2 – 4 equally split doses) during 14 days;
Shigellosis – 8-10 mg/kg (in 2 – 4 equally split doses) during 5 days.
Bactrim solution is to be administered via intravenous infusion within 60 – 90 minutes. Abstain administration via bolus injection or rapid infusion. Bactrim is not suitable for intramuscular administration. Bactrim requires to be diluted with the following proportion – every 5 mL of Bactrim requires addition to 125 mL of 5% dextrose in water. Once dilution with 5% dextrose in water is done, the solution cannot be refrigerated and is to be utilized during the following 6 hours.

Generally Observed Side Effects

Common side effects of Bactrim include:
Appetite loss;
Nausea/vomiting;
Dizziness;
Swelling and pain in tongue;
Head spinning sensations;
Common tiredness;
Ringing sounds in ears;
Sleep disorders (i.e., insomnia).
Inform your doctor right away, if the following serious side effects from Bactrim treatment are observed:
Aplastic anemia;
Bleeding and/or bruising;
Hepatic necrosis;
Jaundice;
Joints pain;
Severe skin rashes;
Mouth sores;
Itchiness;
Sore throat.